Hi. I can understand the trepidation. And here are some tips:
1) Firstly, you have a 75 gallon tank which I am sure would satisfy any female Syrian - its a really good size
2) Check out the cage cleaning tips article (linked below) about avoiding stress (sorry you might know all this already). To me, the most important thing is getting everything set up before they arrive - and then never change a thing! Not unless absolutely essential or something breaks. They really do thrive with the security and stability of familiarity.
3) Don't worry too much about spot cleaning the first two weeks if the pee area isn't obvious - better to let her settle and not destroy her tunnels - providing she has plenty of bedding.
4) They all very and from what I understand most females have incredibly sweet personalities, even if they go a bit hyperactive one day out of every four. Very affectionate (I say apparently, I've only had a female dwarf). I have never heard of a vicious female.
5) Give her old cardboard egg boxes to rip up, it'll keep her happy
6) Even in a really large cage, they still need out of cage time IMO - so if you can rig up an area for a large playpen, and get her handleable, so she might be able to free roam in future, you will both probably have a happy existence.
7) I have never had a female Syrian but - I have had a male Syrian who behaved like a super active female! He wanted to be out every single night - as much as possible. He owned the living room. He would give incredibly sweet and affectionate bonding looks but be very funny and cheeky.
So I'd say - love her for what she is

I think you'll be fine with a nice big glass tank and if the previous owner has been having issues, she could behave completely differently with you. Just be calm

It can often set up a cycle of stress and frustration between hamster and owner, when they start chewing out of wood cages. It's a terrible mix - a female syrian and a wood cage IMO!
I know there's the worry about the future and things like pyometra. However many many hamster owners have had female syrians for a good long life, and no sign of anything like that. It's like humans - it's just luck and genetics.
People I know who keep Syrians (including an NHC breeder) have said they love the girls best because they're so affectionate. Males can be a bit reclusive sometimes. Although I tame them so they stop being reclusive!
