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I don't know much about rats
I know it's quite complicated with hamsters and even the vets struggle to work it out. Because they work out the dosage for weight and then have to factor in the hamster's metabolism. Sometimes takes them ages doing a load of maths! One vet said it was realised they had been underdosing hamsters for years by not factoring in their metabolism (which is different to that of a cat or dog). Shame they don't make rodent specific metacam.
